MSigDB v5.2 Release Notes

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This page describes the changes made to the gene set collections for Release 5.2 of the Molecular Signatures Database (MSigDB).

C2: Curated gene sets (+4)

• CGP: chemical and genetic perturbations (+4 gene sets).
• CP: canonical pathways.

C5: GO gene sets (+4712)

Gene sets in this new collection are derived from the controlled vocabulary of the Gene Ontology (GO) project: The Gene Ontology Consortium. Gene Ontology: tool for the unification of biology. Nature Genet. (2000) 25: 25-29 (http://www.geneontology.org/). The gene sets are named by GO term and contain genes annotated by that term.

This collection is divided into three subcollections:

• CC: GO Cellular component (+584 gene sets). Gene sets derived from the Cellular Component Ontology.
• MF: GO Molecular function (+929 gene sets). Gene sets derived from the Molecular Function Ontology.
• BP: GO Biological process (+4653 gene sets). Gene sets derived from the Biological Process Ontology.

 GSEA users: Gene set enrichment analysis identifies gene sets consisting of co-regulated genes; GO gene sets are based on ontologies and do not generally consist of co-regulated genes.

For more information

For complete descriptions of all collections or to download the updated gene sets, go to the Browse Collections page.