Gsea Algorithm

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<a href="http://www.broad.mit.edu/gsea/">GSEA Home</a> |  <a href="../../software/software_index.html">Software</a> | <a href="http://www.broad.mit.edu/gsea/msigdb/">MSigDB</a> | [[Main_Page|Documentation]] | <a href="../../resources/resources_index.html">Resources</a>  <br />
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<a href="http://www.broad.mit.edu/gsea/">GSEA Home</a> |  <a href="http://www.broad.mit.edu/gsea/downloads.jsp">Downloads</a> | <a href="http://www.broad.mit.edu/gsea/msigdb/">Molecular Signatures Database</a> | Documentation | <a href="http://www.broad.mit.edu/gsea/contact.jsp">Contact</a>  <br />
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<p class="MsoNormal">Gene Set Enrichment Analysis (GSEA) is a computational method that determines whether an <em>a priori</em> defined set of genes shows statistically significant, concordant differences between two biological states (e.g. phenotypes). The algorithm is described in the following paper and supplementary information:<br />
<p class="MsoNormal">Gene Set Enrichment Analysis (GSEA) is a computational method that determines whether an <em>a priori</em> defined set of genes shows statistically significant, concordant differences between two biological states (e.g. phenotypes). The algorithm is described in the following paper and supplementary information:<br />
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<div style="margin-left: 40px;"> Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S. &amp; Mesirov, J. P. (2005) Proc. Natl. Acad. Sci. USA 102, 15545-15550.<span style="font-weight: bold;"> <strong>Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression            profiles. </strong></span>[http://www.broad.mit.edu/cancer/software/gsea/doc/subramanian_tamayo_gsea_pnas.pdf pdf]<br />
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<div style="margin-left: 40px;"> Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S. &amp; Mesirov, J. P. (2005) Proc. Natl. Acad. Sci. USA 102, 15545-15550.<span style="font-weight: bold;"> <strong>Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression            profiles. </strong></span>[http://www.broad.mit.edu/gsea/doc/subramanian_tamayo_gsea_pnas.pdf pdf]<br />
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<span style="font-weight: bold;">            <span style="font-weight: bold;">Supplementary info for Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide            expression            profiles.</span><span style="text-decoration: underline;"> </span></span>[http://www.broad.mit.edu/cancer/software/gsea/doc/subramanian_tamayo_gsea_pnas_supp_info.pdf pdf] <br />
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<span style="font-weight: bold;">            <span style="font-weight: bold;">Supplementary info for Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide            expression            profiles.</span><span style="text-decoration: underline;"> </span></span>[http://www.broad.mit.edu/gsea/doc/subramanian_tamayo_gsea_pnas_supp_info.pdf pdf] <br />
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Examples from the GSEA paper are provided [http://www.broad.mit.edu/cancer/software/gsea/resources/datasets_index.html here].<span style="font-weight: bold;"><br />
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Examples from the GSEA paper are provided [http://www.broad.mit.edu/gsea/resources/datasets_index.html here].<span style="font-weight: bold;"><br />
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Revision as of 21:45, 18 December 2007

<a href="http://www.broad.mit.edu/gsea/">GSEA Home</a> | <a href="http://www.broad.mit.edu/gsea/downloads.jsp">Downloads</a> | <a href="http://www.broad.mit.edu/gsea/msigdb/">Molecular Signatures Database</a> | Documentation | <a href="http://www.broad.mit.edu/gsea/contact.jsp">Contact</a>


Gene Set Enrichment Analysis (GSEA) is a computational method that determines whether an a priori defined set of genes shows statistically significant, concordant differences between two biological states (e.g. phenotypes). The algorithm is described in the following paper and supplementary information:

Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S. & Mesirov, J. P. (2005) Proc. Natl. Acad. Sci. USA 102, 15545-15550. Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. pdf


Supplementary info for Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. pdf

Examples from the GSEA paper are provided here.

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