Gsea Algorithm

From GeneSetEnrichmentAnalysisWiki

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<a href="http://www.broadinstitute.org/gsea/">GSEA Home</a> |  
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[http://www.broadinstitute.org/gsea/ GSEA Home] |
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<a href="http://www.broadinstitute.org/gsea/downloads.jsp">Downloads</a> |  
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[http://www.broadinstitute.org/gsea/downloads.jsp Downloads] |  
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<a href="http://www.broadinstitute.org/gsea/msigdb/">Molecular Signatures Database</a> |  
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[http://www.broadinstitute.org/gsea/msigdb/ Molecular Signatures Database] |  
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<a href="http://www.broadinstitute.org/cancer/software/gsea/wiki/index.php/Main_Page">Documentation</a> |
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[http://www.broadinstitute.org/cancer/software/gsea/wiki/index.php/Main_Page Documentation] |
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<a href="http://www.broadinstitute.org/gsea/contact.jsp">Contact</a>
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[http://www.broadinstitute.org/gsea/contact.jsp Contact]
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<p>Gene Set Enrichment Analysis (GSEA) is a computational method that determines whether an <em>a priori</em> defined set of genes shows statistically significant, concordant differences between two biological states (e.g. phenotypes).</p>
<p>Gene Set Enrichment Analysis (GSEA) is a computational method that determines whether an <em>a priori</em> defined set of genes shows statistically significant, concordant differences between two biological states (e.g. phenotypes).</p>

Current revision as of 07:05, 25 September 2016

GSEA Home | Downloads | Molecular Signatures Database | Documentation | Contact

Gene Set Enrichment Analysis (GSEA) is a computational method that determines whether an a priori defined set of genes shows statistically significant, concordant differences between two biological states (e.g. phenotypes).

The algorithm is described in the following paper and supplementary information:

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles.
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S. & Mesirov, J. P.
Proc. Natl. Acad. Sci. USA (2005) 102:15545-50. PDF

Supplementary Information for
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles.pdf

Examples from the GSEA paper are provided here.

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