MSigDB v2022.1.Hs Release Notes

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Important Notices

This page describes updates made to the Molecular Signatures Database for release 2022.1. This release introduces several major changes to previous conventions. MSigDB is now split into two major divisions; a series of gene set collections that are provided in the namespace of human gene symbols, and a series of gene set collections that are provided in the namespace of mouse gene symbols. As such the versioning convention of MSigDB has changed to adopt the format Year.Release.Species. This initial release in the new format is versioned 2022.1.Hs for the human collections and 2022.1.Mm for the mouse collections. Likewise, CHIP files have been updated to reflect this convention, as well as the specific series of collections (i.e. human or mouse) that they are targeted towards.

Note that in order to access the MSigBD mouse collections through the GSEA UI, the latest version of GSEA (4.3.0) is required.

MSigDB v2022.1 is based on gene annotation data from Ensembl Release 107 (Jul 2022).

Updates to Human Collections (MSigDB v2022.1.Hs)

C1

Updated human gene annotations to Ensembl 107 (+XX gene sets).

C2:CGP

Gene sets contributed by the following individuals have been added to C2:CGP

• (PMID:)

C2:CP:Reactome

• Reactome gene sets have been updated to reflect the state of the Reactome pathway architecture as of Reactome v81 (+XX gene sets).
• As previously described in the Reactome release notes for MSigDB 7.0, in order to limit redundancy between gene sets within the Reactome sub-collection we applied a filtering procedure based on Jaccard coefficients and distance from the top level of the Reactome event hierarchy.

C2:CP:WikiPathways

WikiPathways gene sets have been updated to the August 10, 2022 release (+XX gene sets).

C5:GO (Gene Ontology)

Gene sets in these sub-collections are derived from the controlled vocabulary of the Gene Ontology (GO) project: The Gene Ontology Consortium. Gene Ontology: tool for the unification of biology (Nature Genet 2000). The gene sets are named by GO term and contain genes annotated by that term. This collection has been updated to the most recent GO annotations as present in the GO-basic obo file released on 2022-07-01 and NCBI gene2go annotations downloaded on 2022-07-15.

This collection is divided into three sub-collections:

• BP: GO Biological process (+XX gene sets). Gene sets derived from the Biological Process Ontology, and are prefixed with "GOBP_".
• CC: GO Cellular component (+XX gene sets). Gene sets derived from the Cellular Component Ontology, and are prefixed with "GOCC_".
• MF: GO Molecular function (+XX gene sets). Gene sets derived from the Molecular Function Ontology, and are prefixed with "GOMF_"..

These updates were generated in accordance with the procedure described in the GO release notes for MSigDB 7.0.

C5:HPO (Human Phenotype Ontology)

Gene sets in this sub-collection have been updated to reflect the 2022-06-11 release of the Human Phenotype Ontology database (+XX gene sets). This sub-collection has been redundancy filtered through a procedure comparable to that of the GO and Reactome sub-collections.

CHIP file updates

• MSigDB 2022.1.Hs gene annotations and gene mapping CHIP files have been updated to data from Ensembl 107.
• Gene orthology annotations for mapping mouse and rat genes to their best match human orthologs have been updated to Alliance of Genome Resources orthology database release 5.2.1 (2022-07-15)
• Rat Microarray annotations derived from mappings to the mRatBN7.2 assembly are now available, the previous warning associated with remapped data from the deprecated Rnor_6.0 assembly has been removed.