MSigDB v5.2 Release Notes

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This page describes the changes made to the gene set collections for Release 5.2 of the Molecular Signatures Database (MSigDB).


C2: Curated gene sets (+4)

  • CGP: chemical and genetic perturbations (+4 gene sets).
  • CP: canonical pathways.

C5: GO gene sets (-1454 + 6166)

Gene sets in this new collection are derived from the controlled vocabulary of the Gene Ontology (GO) project: The Gene Ontology Consortium. Gene Ontology: tool for the unification of biology. Nature Genet. (2000) 25: 25-29 ( The gene sets are named by GO term and contain genes annotated by that term.

This collection is divided into three subcollections:

  • CC: GO Cellular component (+233 gene sets). Gene sets derived from the Cellular Component Ontology.
  • MF: GO Molecular function (+396 gene sets). Gene sets derived from the Molecular Function Ontology.
  • BP: GO Biological process (+825 gene sets). Gene sets derived from the Biological Process Ontology.

 GSEA users: Gene set enrichment analysis identifies gene sets consisting of co-regulated genes; GO gene sets are based on ontologies and do not generally consist of co-regulated genes.

C6 gene sets

C7 gene sets

For more information

For complete descriptions of all collections or to download the updated gene sets, go to the Browse Collections page.

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