Allele specific Rank Sum Test for insert sizes of REF versus ALT reads
INFO=<ID=AS_InsertSizeRankSum,Number=A,Type=Float,Description="Allele-specific Insert Size Rank Sum">
This variant-level annotation compares the insert sizes of reads supporting the reference allele with those supporting each alternate allele. To be clear, it does so separately for each alternate allele.
The ideal result is a value close to zero, which indicates there is little to no difference. A negative value indicates that the reads supporting the alternate allele are associated with smaller insert sizes than those supporting the reference allele. Conversely, a positive value indicates that reads supporting the alternate allele are associated with larger insert sizes than those supporting the reference allele. Finding a statistically significant difference either way suggests that the sequencing process may have been biased or affected by an artifact.
The value output for this annotation is the u-based z-approximation from the Mann-Whitney-Wilcoxon Rank Sum Test for insert sizes (insert sizes of reads supporting REF vs. insert sizes of reads supporting ALT). See the method document on statistical tests for a more detailed explanation of the ranksum test.
GATK version 3.8-0-ge9d806836 built at 2017/07/29 01:40:22.