Allele-specific likelihood-based test for the consanguinity among samples (AS_InbreedingCoeff)
This annotation estimates whether there is evidence of inbreeding in a population. The higher the score, the higher the chance that there is inbreeding.
The calculation is a continuous generalization of the Hardy-Weinberg test for disequilibrium that works well with limited coverage per sample. The output is the F statistic from running the HW test for disequilibrium with PL values. See the method document on statistical tests for a more detailed explanation of this statistical test.
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GATK version 4.0.4.0 built at 23-40-2018 11:40:56.