Analysis Summary

Job ID is 1265437411		TIME: 2010-02-06 1:23:31

Using the JPT+CHB Human HapMap and the HG18 Assembly of the Human Genome
The Functional Datasource is text_2006_12

Using default gene list (18875 genes):
http://www.broadinstitute.org/mpg/grail/functionDatabases/text_2006_12/allHumanGenes
A total of 18875 genes in this list

Queries and Seed Regions are set equal
There are 98 valid Query regions
125 query genes within gene list analyzed



Genomic Regions


For full set of genes used in the analysis for each genomic region click here:
	Query Regions	Seed Regions


REGION	GRAIL p-value	CANDIDATE GENE(S)
------	-------------	-----------------
rs1928327	N/A	
rs2317080	N/A	
rs12406116	0.34519601	NTNG1
rs2500097	0.14565384	RGL1
rs1499602	0.32897511	CRB1
rs10900520	0.67826721	LAX1
rs12049605	0.67826721	LAX1
rs4951031	0.67826721	LAX1
rs9970867	0.67826721	LAX1
rs2001890	0.96255689	WDR26
rs7606752	0.99972025	RDH14
rs1223162	0.059472267	PREPL
rs6731423	0.11903863	MXD1
rs11678304	N/A	
rs2862482	N/A	
rs4663942	0.79925111	ASB1
rs2255401	0.70478508	MYRIP
rs17075630	0.72689802	TMEM16K
rs3772902	0.13516814	GBE1
rs11127741	0.13516814	GBE1
rs488416	0.15513566	STXBP5L
rs590436	0.15513566	STXBP5L
rs1688684	0.15513566	STXBP5L
rs3914745	0.15513566	STXBP5L
rs7635903	0.15513566	STXBP5L
rs1191296	0.15513566	STXBP5L
rs1511432	0.15513566	STXBP5L
rs7632907	0.15513566	STXBP5L
rs4676677	0.15513566	STXBP5L
rs9845025	0.86799996	SCHIP1
rs9865997	0.86799996	SCHIP1
rs10513658	0.7737222	EVI1
rs2861835	0.16702559	NLGN1
rs2030033	0.44346692	BCL6
rs6448447	N/A	
rs4373155	N/A	
rs4622992	N/A	
rs17282228	0.057134368	EREG
rs13117589	0.24782071	PPP3CA
rs2201677	0.24782071	PPP3CA
rs4698838	0.24782071	PPP3CA
rs4698981	0.24782071	PPP3CA
rs7658148	0.86630693	GALNT7
rs17166585	0.53366825	FSTL4
rs11960384	0.53366825	FSTL4
rs10515460	0.53366825	FSTL4
rs17166631	0.53366825	FSTL4
rs7449290	0.48568853	ODZ2
rs7732626	0.2866792	NSD1
rs942631	0.35396936	GCNT2
rs4401656	0.97285357	CDKAL1
rs517924	0.50432757	FOXO3
rs9486920	0.50432757	FOXO3
rs2008819	0.053985221	RALA
rs11982634	0.053985221	RALA
rs13224312	0.053985221	RALA
rs2107710	0.053985221	RALA
rs9639874	0.38778768	HECW1
rs7794076	0.38778768	HECW1
rs11976696	0.25682112	EGFR
rs10486940	0.28162296	CACNA2D1
rs10092922	0.13926316	SGCZ
rs6990315	0.2591321	SGCZ
rs1445403	0.14302915	EYA1
rs6469297	0.24883852	KCNV1
rs12342114	0.33046787	GNA14
rs2182049	0.79993543	FKBP15
rs2067653	N/A	
rs4573574	N/A	
rs1484398	0.92679829	TSPAN18
rs7124728	N/A	
rs957438	0.2154109	DLG2
rs7300256	0.21216047	SRGAP1
rs10859071	0.58184158	KERA
rs9316393	0.85298561	ITM2B
rs12877288	0.85298561	ITM2B
rs4904524	0.55003093	FOXN3
rs3759711	0.55003093	FOXN3
rs7178315	0.070660275	OCA2
rs2279578	0.051742846	RHOV
rs2255235	0.95997508	B2M
rs9926693	0.68011013	CNGB1
rs9818	0.79504646	RTN4RL1
rs10514133	0.88576638	CNDP1
rs1030689	0.34433763	ZNF507
rs12610340	0.34433763	ZNF507
rs1497764	0.064791249	FKRP
rs17211605	0.7948959	PI4KA
rs926336	0.14687546	RASD2
rs8137243	0.92972139	WNT7B
rs2269368	0.034923424	MECP2
rs1557501	0.034923424	MECP2
rs17422	0.034923424	MECP2
rs2266888	0.034923424	MECP2
rs6571303	0.034923424	MECP2
rs1059702	0.034923424	MECP2
rs2734647	0.034923424	MECP2
rs2239464	0.034923424	MECP2



Keywords Describing Functional Connections

'syndrome'
'mutations'
'branching'
'patients'
'congenital'
'muscular'
'dystrophy'
'mutation'
'glycogen'
'corneal'
'gtpase'
'zeta'
'recessive'
'deletion'
'beta'
'phenotype'
'syntaxin'
'deletions'
'retinal'
'severe'



GRAIL data for selected individual genes of interest

GENE	GRAIL p-value	SELECTED SIMILAR GENES (Rank in parantheses)
----	-------------	--------------------------------------------
MECP2	0.0050653885	NTNG1(6), NSD1(13), VPS13A(166), OCA2(258), EYA1(336), FKRP(355), HMGB2(497), VPS18(551)
FKRP	0.013307761	SGCZ(65), CRB1(93), VPS13A(122), NSD1(137), GBE1(180), OCA2(624)
PREPL	0.015211652	SLC3A1(2), NSD1(6), PPM1B(30), SLC1A5(33), SNRK(122), ZC3H11A(127), CNDP2(342), VPS13A(346), ZNF507(412), ZNF407(576)
RHOV	0.026215037	ARHGAP4(52), SRGAP1(122), WNT7B(137), RALA(170), RAB24(230), PAK1IP1(235), SNRK(278), PI4KA(287), PPM1B(440), RGL1(464), CSNK2A2(518), SLC1A5(610)
RALA	0.02736709	RGL1(6), ARHGAP4(172), RAB24(220), RHOV(280), RASD2(316), EGFR(485), PI4KA(506), HMGB2(527)
MXD1	0.031188654	MXD3(1), RB1(113), HMGB2(245), BCL6(410), WNT7B(441), CSNK2A2(623)
STXBP5L	0.054643401	SNAP29(17), ZC3H11A(139), ZNF507(151), ZNF407(178), SRGAP1(351), WDR26(564)
EREG	0.057134368	EGFR(5), FGFR4(173), SNRK(260), ODZ2(332), WNT7B(471)
NSD1	0.065332855	PREPL(79), MECP2(143), EYA1(146), OCA2(189), VPS13A(254), EVI1(543), FKRP(586)
OCA2	0.070660275	CNDP2(112), VPS18(126), VPS13A(147), NSD1(206), POLQ(228), WNT7B(346), B2M(356)
MXD3	0.074715805	MXD1(1), RB1(141), WNT7B(322), HMGB2(390), SNRK(620)
ARHGAP4	0.096649553	SRGAP1(42), RHOV(118), SNRK(201), RALA(311), PI4KA(381), RAB24(427), CNDP2(516), ARD1A(527)
PRKD2	0.11263004	CSNK2A2(42), SNRK(62), PI4KA(95), EGFR(232), CRKL(284), IRAK1(417)
CRB1	0.12452004	FKRP(148), OCA2(197), VPS13A(238), WNT7B(380), NSD1(446), VPS18(447), ODZ2(472), EYA1(498), CNDP2(508), CNGB1(572)
GBE1	0.13516814	GCNT2(40), ANXA4(82), FKRP(113), VPS13A(125), TMEM14C(336), NSD1(471), TUSC3(594)
GCNT2	0.13552778	B2M(54), WNT7B(249), GBE1(324), PPM1B(329), SNRK(451), TUSC3(575)
DACT3	0.13771856	WNT7B(15), EYA1(371), ODZ2(456)
SGCZ	0.13926316	FKRP(19), TUSC3(76), CACNA2D1(106), B2M(364), ARD1A(543), ODZ2(572)
EYA1	0.14302915	WNT7B(40), NSD1(133), VPS18(307), ODZ2(327)
RGL1	0.14565384	RALA(6), TMEM14C(126), C2orf34(323)
RASD2	0.14687546	RALA(151), RGL1(244), SNRK(318), WNT7B(420), GNA14(437), ARHGAP4(516)
CNGB1	0.15026054	CACNA2D1(21), KCNV1(113), TUSC3(330)
ANXA4	0.15509749	GBE1(122), SNRK(129), PI4KA(225), CSNK2A2(302), GCNT2(413), HMGB2(484), WNT7B(494), CNDP2(536)
NLGN1	0.16702559	DLG2(21), SNAP29(290), ODZ2(498)
RAB24	0.16715284	RALA(185), ARHGAP4(191), RGL1(240), RHOV(326), SNRK(329), PI4KA(331), CSNK2A2(338)
GNA14	0.18175057	WDR26(108), CACNA2D1(148), CSNK2A2(242), P2RY5(301), TUSC3(462), B2M(534)
FKBP15	0.18220157	ZC3H11A(17), ZNF407(97), ZNF507(189)
FGFR4	0.1851745	EGFR(40), WNT7B(138), SNRK(258), CSNK2A2(402), PI4KA(420)
NTNG1	0.1908004	MECP2(14), NSD1(167), CNDP2(222), ZC3H11A(343), CNDP1(404), VPS13A(598)
KERA	0.19585343	LUM(2), EPYC(26), WNT7B(78), VPS13A(355), GCNT2(426), SNRK(480), CNDP2(485), ODZ2(601)
SNX30	0.20515075	PI4KA(27), VPS13A(80), CNIH4(247), TUSC3(414), PAK1IP1(587)
SRGAP1	0.21216047	ARHGAP4(29), ZNF407(52), ZC3H11A(142), ZNF507(389)
DLG2	0.2154109	NLGN1(66), CACNA2D1(309), SNRK(463), SNAP29(577)
SLC3A1	0.24188957	PREPL(3), SLC1A5(5), SNRK(190), SLC31A1(318), VPS13A(583), PAK1IP1(586)
PPP3CA	0.24782071	PPM1B(75), CSNK2A2(172), CACNA2D1(260), PI4KA(473), SNRK(506), B2M(546), EGFR(607)
RY1	0.24847995	TMEM14C(7), CDKAL1(338), C2orf34(361), C16orf57(378)
PPM1B	0.24851727	SNRK(41), ZC3H11A(191), TMEM14C(263), CNDP2(390), CSNK2A2(501)
KCNV1	0.24883852	CACNA2D1(57), CNGB1(91), SNRK(294), DLG2(582)
BCL6	0.25398856	EVI1(167), B2M(288), RB1(299), LPP(307), HMGB2(410), FOXO3(534), PRELID1(566)
EGFR	0.25682112	EREG(37), FGFR4(191), CSNK2A2(259), PI4KA(428)
CSNK2A2	0.26726587	PI4KA(109), SNRK(220), EGFR(367), TUSC3(398), HMGB2(487)
CACNA2D1	0.28162296	CNGB1(47), KCNV1(123), PPM1B(449), GNA14(513), CSNK2A2(597)
EPYC	0.28442241	KERA(34), LUM(42), SERPIND1(119), SNRK(194), WNT7B(277), ZC3H11A(398), PPM1B(407), ODZ2(450)
LAX1	0.31477725	CRKL(98), PI4KA(151), EGFR(276), CSNK2A2(339), FOXO3(436), B2M(532), BCL6(565)
ITM2B	0.31849041	B2M(60), ARD1A(246), CNDP2(263), SNRK(318), VPS13A(418)
SLC1A5	0.31910677	SLC3A1(22), SLC31A1(141), SNRK(152), PPM1B(375), CSNK2A2(573)
LUM	0.3208799	KERA(1), EPYC(17), B2M(129), WNT7B(209), SNRK(246)
PI4KA	0.32703328	SNX30(64), CSNK2A2(88), SNRK(147), TUSC3(368), EGFR(522)
LPP	0.33392401	HMGB2(137), SNRK(227), CNDP2(237), CSNK2A2(535), ZC3H11A(606)
ZNF507	0.34433763	ZC3H11A(38), ZNF407(72)
GMCL1	0.34607744	VPS18(158), WNT7B(163), ODZ2(231), C2orf34(500), TMEM14C(623)
TMEM16K	0.35120382	VPS18(36), CDKAL1(227), C2orf34(429), C16orf57(444), TMEM14C(512)
RENBP	0.37422506	GCNT2(51), SNRK(190), HMGB2(272), CNDP2(336), CSNK2A2(362), SLC1A5(392), PPM1B(586), PI4KA(596)
POLQ	0.38579337	VPS18(108), HMGB2(259), CNDP2(453), C2orf34(620)
HECW1	0.38778768	ZC3H11A(71), ZNF407(117), ZNF507(458)
CRKL	0.39301898	EGFR(159), CSNK2A2(192), LAX1(252), PI4KA(273)
CNDP1	0.41863554	CNDP2(2), SNRK(144), SLC1A5(185), B2M(423), GCNT2(555)
ABHD5	0.41975468	VPS13A(116), CNDP2(308), NSD1(309), SNRK(389), TMEM14C(477), TUSC3(604), PI4KA(607)
C16orf80	0.43605554	TMEM14C(29), C16orf57(268), CDKAL1(384), C2orf34(532)
SLC31A1	0.43788992	SLC31A2(2), SLC1A5(29), SLC3A1(258), TUSC3(278), PRELID1(502)
ZC3H11A	0.44627363	ZNF407(71), ZNF507(201), C22orf26(479)
RB1	0.45459953	EGFR(335), CSNK2A2(342), WNT7B(377)
P2RY5	0.46682842	GNA14(117), RB1(376), WDR26(475), SNRK(479), EGFR(555)
TSPAN18	0.47984795	TMEM14C(91), C16orf57(124), CDKAL1(288), C2orf34(605)
SLC46A2	0.48170643	SNRK(80), ZC3H11A(223), ZNF407(488), ZNF507(534)
ODZ2	0.48568853	VPS18(153), WNT7B(246), RY1(358), C2orf34(397), TMEM14C(456), CNDP2(483)
SYT13	0.49129722	ZC3H11A(189), ZNF507(277), ZNF407(304)
CYSLTR2	0.50059648	P2RY5(179), EGFR(247), GNA14(475), CACNA2D1(516), B2M(582), SLC1A5(591)
FOXO3	0.50432757	EGFR(196), RB1(251), CSNK2A2(272), WNT7B(461), HMGB2(587)
ZFP37	0.5050978	ZNF319(179), TRIM69(305), EVI1(317), SNRK(410)
SNAP29	0.51725323	STXBP5L(54), C16orf57(241), TMEM14C(267)
ARGFX	0.52341072	GMCL1(102), CDKAL1(232), TMEM14C(276), PRELID1(417), RY1(609)
ZNF407	0.52387608	ZC3H11A(79), ZNF507(201)
MMP15	0.53082812	SNRK(175), CNDP2(471), EGFR(483), PPM1B(487), WNT7B(546)
FSTL4	0.53366825	ZC3H11A(53), ZNF407(360), TMEM14C(467), ZNF507(529)
SERPIND1	0.53870334	CSNK2A2(90), EPYC(365), B2M(425), SNRK(440), HMGB2(504)
VPS18	0.54691841	C2orf34(140), CNDP2(293), ODZ2(399), TMEM14C(563), C16orf57(601)
FOXN3	0.55003093	ZC3H11A(153), TMEM14C(234), POLQ(276), CNDP2(296), VPS13A(552)
ASB1	0.5519499	ZC3H11A(55), ZNF407(368), TMEM14C(476)
STRN4	0.55199298	ZC3H11A(44), C22orf26(236), TMEM14C(594)
CNDP2	0.55388043	TMEM14C(81), CDKAL1(299)
ZNF319	0.57495091	ZC3H11A(106), ZNF407(313), ZNF507(501)
C7orf36	0.59861554	CDKAL1(226), TMEM14C(243), C16orf57(313)
TEPP	0.61114634	FSTL4(212), ZC3H11A(274), SNRK(284)
VPS13A	0.62047474	SNX30(157), VPS18(172), CNDP2(323)
IRAK1	0.62426468	CSNK2A2(294), EGFR(302), PI4KA(479), SNRK(609)
C16orf57	0.63163325	CDKAL1(172), TMEM14C(174), C2orf34(565)
GALNT7	0.63435937	TMEM14C(109), CDKAL1(501), C2orf34(539)
DENND1B	0.64628172	DENND1B(3), CDKAL1(240)
HCFC1	0.64946858	HMGB2(173), RB1(438), CSNK2A2(529)
WDR26	0.66545287	TMEM14C(122), C16orf57(231), CDKAL1(381)
C12orf12	0.66733479	C12orf12(6), C7orf36(332), TRIM69(425)
PRELID1	0.6700808	TMEM14C(62), C16orf57(476)
SNRK	0.67627445	TMEM14C(83), PPM1B(295), CNDP2(397), PI4KA(620)
TP53I11	0.69216795	ZC3H11A(210), RB1(303)
C9orf80	0.69658454	TMEM14C(82), ZC3H11A(241), ZNF407(544)
MYRIP	0.70478508	RAB24(160), RALA(444), SYT13(547)
C1orf53	0.70784756	RB1(83), C9orf80(199), SRGAP1(470), ZNF407(535)
NVL	0.71445573	PAK1IP1(40)
TRAF3IP1	0.7291629	CDKAL1(242), TMEM14C(258), C16orf57(374), C2orf34(492)
WNT7B	0.73489887	ODZ2(347), VPS18(594)
CNIH4	0.73736282	TMEM14C(104)
C2orf34	0.75760946	TMEM14C(254), CDKAL1(306), C16orf57(456)
EVI1	0.7737222	ZNF319(400), SNRK(489), HMGB2(490), WNT7B(588), RY1(610)
RTN4RL1	0.79504646	ODZ2(253), SNRK(421)
B2M	0.79993771	GCNT2(250)
TMEM187	0.8013372	TMEM14C(190), ZC3H11A(383), ARHGAP4(485), CNDP2(551)
RCBTB2	0.80824621	CNDP2(268), RB1(315), TEPP(496), P2RY5(508), RALA(549)
CYB5A	0.81707949	CNDP2(274), TUSC3(276), TMEM14C(415), PRELID1(472), SNRK(533)
ARD1A	0.82266442	TMEM14C(295), TUSC3(498)
PAK1IP1	0.83386116	TMEM14C(66), NVL(255), C16orf57(438), CDKAL1(568)
HMGB2	0.85774794	VPS18(513), TMEM14C(580), ODZ2(620)
SCHIP1	0.86799996	ZC3H11A(133), CNDP2(485)
TMEM14C	0.88109532	C16orf57(300), CDKAL1(350), C2orf34(550)
TRIM69	0.8963622	ZFP37(250), C12orf12(338), ZNF319(448), GMCL1(595)
PRMT6	0.96046164	
SNRPE	0.96257199	TMEM14C(551), HMGB2(580)
TUSC3	0.96460861	CNIH4(327), CNDP2(585)
CDKAL1	0.97285357	C16orf57(322), TMEM14C(379), C2orf34(563)
SLC31A2	0.98194858	SLC31A1(1), C9orf80(98), TMEM14C(458)
RDH14	0.98327439	CNDP2(399), ZC3H11A(580)
PRDM11	0.98809608	LOC169834(202)
NT5C1B	0.99160509	LOC169834(224)
LOC169834	1	LOC169834(193)
C22orf26	1	C22orf26(17), LOC169834(282)