Gene Set: WONG_MITOCHONDRIA_GENE_MODULE

Standard name WONG_MITOCHONDRIA_GENE_MODULE
Systematic name M15112
Brief description Genes that comprise the mitochondria gene module
Full description or abstract A major goal of cancer research is to match specific therapies to molecular targets in cancer. Genome-scale expression profiling has identified new subtypes of cancer based on consistent patterns of variation in gene expression, leading to improved prognostic predictions. However, how these new genetic subtypes of cancers should be treated is unknown. Here, we show that a gene module map can guide the prospective identification of targeted therapies for genetic subtypes of cancer. By visualizing genome-scale gene expression in cancer as combinations of activated and deactivated functional modules, gene module maps can reveal specific functional pathways associated with each subtype that might be susceptible to targeted therapies. We show that in human breast cancers, activation of a poor-prognosis wound signature is strongly associated with induction of both a mitochondria gene module and a proteasome gene module. We found that 3-bromopyruvic acid, which inhibits glycolysis, selectively killed breast cells expressing the mitochondria and wound signatures. In addition, inhibition of proteasome activity by bortezomib, a drug approved for human use in multiple myeloma, abrogated wound signature expression and selectively killed breast cells expressing the wound signature. Thus, gene module maps may enable rapid translation of complex genomic signatures in human disease to targeted therapeutic strategies.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 18199530   Authors: Wong DJ,Nuyten DS,Regev A,Lin M,Adler AS,Segal E,van de Vijver MJ,Chang HY
Exact source Table 2S
Related gene sets (show 1 additional gene sets from the source publication)

(show 129 gene sets from the same authors)
External links  
Organism Homo sapiens
Contributed by Jessica Robertson (MSigDB Team)
Source platform HUMAN_GENE_SYMBOL
Dataset references (show 2 datasets)
Download gene set format: grp | text | gmt | gmx | xml
Compute overlaps (show collections to investigate for overlap with this gene set)
Compendia expression profiles Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 218 genes
Gene families Categorize these 218 genes by gene family
Show members (show 218 members mapped to 218 genes)
Version history 3.0: First introduced

See MSigDB license terms here. Please note that certain gene sets have special access terms.