Molecular Signatures Database v6.0

GSEA and MSigDB Need Your Support

Dear GSEA/MSigDB user,

Last November we submitted a proposal to NCI's Information Technology for Cancer Research program for the continued funding of the Gene Set Enrichment Analysis (GSEA) software and the Molecular Signatures Database (MSigDB). Despite scoring well, our proposal was not funded in this round, and we were encouraged to resubmit for the next one. Notably, our score would have ensured funding in previous rounds. This funding is critical for our continuing support and enhancement of this important resource for the the biomedical research community.

For our original submission many of you sent us emails of support, an important requirement for these ITCR proposals. We now ask for your help again with this resubmission. If you are concerned about the continued availability of the GSEA/MSigDB resource, we would greatly appreciate a short email expressing the value of the resource to your work and your concerns about the possibility of discontinued funding.

Please send your emails to on or before Thursday June 1, 2017.

Thanks in advance for your help and support.
The GSEA/MSigDB Team.


The Molecular Signatures Database (MSigDB) is a collection of annotated gene sets for use with GSEA software. From this web site, you can

  • Search for gene sets by keyword.
  • Browse gene sets by name or collection.
  • Examine a gene set and its annotations. See, for example, the GO_NOTCH_SIGNALING_PATHWAY gene set page.
  • Download gene sets.
  • Investigate gene sets:
    • Compute overlaps between your gene set and gene sets in MSigDB.
    • Categorize members of a gene set by gene families.
    • View the expression profile of a gene set in a provided public expression compendia.

License Terms

GSEA and MSigDB are available for use under these license terms.

Please register to download the GSEA software, access our web tools, and view the MSigDB gene sets. After registering, you can log in at any time using your email address. Registration is free. Its only purpose is to help us track usage for reports to our funding agencies.


The MSigDB gene sets are divided into 8 major collections:

Citing the MSigDB

To cite your use of the Molecular Signatures Database (MSigDB), please reference Subramanian, Tamayo, et al. (2005, PNAS 102, 15545-15550) and also the source for the gene set as listed on the gene set page.

Current Version

MSigDB database v6.0 updated April 2017. Release notes.
GSEA/MSigDB web site v6.1 released May 2017


The MSigDB is maintained by the GSEA team. We also welcome and appreciate contributions to this shared resource and encourage users to submit their gene sets to Our thanks to our many contributors.

Funded by: National Cancer Institute, National Institutes of Health, National Institute of General Medical Sciences.