Web site v3.87 Release Notes

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Release 3.87 of the GSEA/MSigDB web site contains several updates and bug fixes, including:

  • Compute Overlaps now supports multiple hypothesis testing and outputs false discovery rate (FDR) q-values, as well as hypergeometric p-values.  For more information, see the Compute Overlaps Help page.
  • Compute Overlaps is now improved so that p-values are more readily comparable across collections. Previously, N (the population of genes, also known as the gene universe) was defined as the genes in the sets selected for testing plus the genes in the input list. This caused N to be different between runs of Compute Overlaps, so that the p-values were not always directly comparable between runs. The revised procedure defines the gene universe as all human gene symbols derived from the current version of the human Entrez Gene IDs, which provides a standard N = 46576, now used throughout Compute Overlaps. For more information, see the Compute Overlaps Help page
  • Fixing broken links for downloading some gene set collections from About Collections page.
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